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Customized recombinant cell lines expressing G protein coupled receptors
Euroscreen FAST is now offering fully customized development for cell lines including characterization in radioligand binding and multiple functional assays, starting at 15,000€/$20,000.
Research solutions & optimized assays for your specific R&D programs
The largest GPCR Assay Catalogue offers more than 300 recombinant G protein coupled receptors (GPCRs) expressed in stable clonal cell lines and validated in more than 600 radioligand binding and various functional assays. In 2010, Euroscreen FAST has also initiated a collaboration with InVitrogen Life Sciences to offer the TANGO technology for beta-arrestin assays. In addition, we offer our 15 years of GPCR expertise to help clients develop assays for receptor mutants, orthologous GPCRs, heterodimers, and functional antibody screening.
High Throughput Functional Screening Platform
Our platform can screen up to 300,000 compounds in 15 days using different GPCR assays. Our programs include assay development and validation, HTS, confirmation of positives, dose response curves of confirmed actives and selectivity determination.
Reliable partnerships for Hit-to-lead and lead-optimization programs
Characterization of your compounds in one or more of our assays (cAMP, IPOne, Aequorin, GTPYS, radioligand binding assay, beta-arrestin, or customized assays) to determine agonist, antagonist or allosteric modulator potency, efficacy and functional selectivity with your data returned 5 days after compound delivery for repetitive testings.
GPCR Functional Profiling
We provide a diversity functional profile of 56 human GPCRs, profiles to test allosteric modulators, specific receptor family panels (e.g. human and mouse chemokine, human serotonin, human mGlu receptors), therapeutic area and safety panels, as well as customized panels that you design from our assays.
GPCR deorphanization
Euroscreen FAST has the largest collection of human and animal tissue extracts and recombinant cell lines expressing orphan human receptors for use in deorphanization programs, as well as 15 years of expertise and a successful track record in this area.
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